The drug is excreted generally from the urine, mostly as inactive metabolites and tiny quantities of no cost and conjugated morphine. Negligible quantities of codeine and its metabolites are present in the feces.
If you find yourself getting this medicine, it is particularly critical that the Health care Skilled know When you are getting any of the medicines detailed underneath. The subsequent interactions happen to be picked on The premise of their likely importance and are not essentially all-inclusive.
Drug interactions might change how your prescription drugs work or improve your chance for significant side effects. This doc isn't going to comprise all achievable drug interactions.
Get this medication by mouth with or without foodstuff as directed by your health care provider, generally each four to 6 hours as essential. Since dosing tips may possibly fluctuate, diligently abide by your medical doctor's Instructions for taking this medication.
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Pediatric Usage of Promethazine VC with codeine oral liquid in youngsters and Promethazine, phenylephrine, and codeine oral Answer in young children more youthful than twelve decades of age is just not encouraged. It really should not be made use of To alleviate ache immediately after surgical treatment to eliminate tonsils or adenoids in almost any kids. Critical respiration troubles and deaths are already claimed in certain children who obtained codeine following tonsil or adenoid operation. Geriatric Proper studies performed to date haven't demonstrated geriatric-unique issues that would limit the usefulness of codeine, phenylephrine, and promethazine mix within the aged.
Promethazine: Promethazine is often a phenothiazine spinoff which differs structurally from your antipsychotic phenothiazines because of the presence of a branched facet chain and no ring substitution.
Go ahead and take medication to some medication take-back again system. Examine along with your pharmacy or regulation enforcement to locate a spot.
Ahead of making use of this medication, women of childbearing age ought to talk with their medical professional(s) with regards to the threats and Gains. Explain to your health practitioner If you're pregnant or Imagine you could be Expecting. In the course of pregnancy, this medication is not really encouraged. It may well slightly raise the Promethazine codeine syrup chance of start defects if utilized throughout the initial two months of pregnancy. Also, using it for a long time or in high doses near the predicted supply day may harm the unborn newborn.
In accordance with their plea agreements, Rogers and Wolf conspired, around numerous a long time, in distributing a lot of fraudulent prescriptions for Promethazine-Codeine syrup, which had been despatched to pharmacies in various Kentucky spots. Neither Rogers nor Wolf had valid prescriptions for codeine cough syrup in their unique title. As an alternative, Rogers and Wolf acquired id information and facts from unsuspecting folks – normally in the shape of driver’s licenses.
Promethazine hydrochloride and codeine phosphate must be specified to some Expecting woman provided that clearly wanted.
Promethazine ought to be applied cautiously in folks with cardiovascular disease or with impairment of liver operate.
Because recurrences of NMS are noted with phenothiazines, the reintroduction of promethazine HCl must be very carefully deemed.